Results and DiscussionsIn this experiment the synthesis of acetylsalicylic acid became possible through the induction of an acetyl functional group into a chemical compound or simply acetylation.
Aspirin, acetylsalicylic acid, is a familiar drug, used for relieving cold and flu symptoms, fevers, and general aches and pains in the body, and, as made clear by its chemical formula, contains salicin — a chemical found in willow bark. In the following experiment, Aspirin was synthesized and analyzed in a laboratory setting in order to recognize the chemical process behind a common drug like aspirin and to relate it to the conceptual study of organic chemistry.
The initial step of the experimental process was the synthesis of Aspirin, which required the reaction of salicylic acid, acetic anhydride, and phosphoric acid to produce aspirin and acetic acid.
This reaction is represented visually below: As shown in the above reaction, phosphoric acid, H3PO4 acts as a catalyst in the initial mixture of the reactants in order to speed up the reaction. After aspirin synthesis was complete, the aspirin was analyzed using both IR and NMR spectrometers in order to determine the hydrogen atoms and organic functional groups present in the synthesized aspirin and to verify the overall identity of the aspirin.
To begin the experiment, 2. Salicylic acid was a white, chalky powder; acetic anhydride a clear, colorless liquid; and phosphoric acid a clear, yellow-tinted liquid. The final mixture, a clear, colorless liquid, was stirred occasionally and the temperature of the water was monitored.
After 15 minutes of maintained heat, the flask was removed from the water and 2 mL of DI water was added, producing an aromatic vapor. After the vapor dissipated, a second volume of DI water, 20 mL, was added.
The flask was then scratched on the bottom and placed in an ice bath to encourage crystallization. While the mixture in the flask cooled, a vacuum filtration system was created, and once crystallization occurred, the mixture was poured through the system so as to pull the liquid in the mixture through to the flask, leaving white, powdery crystals on the filter paper.
The crystals were then washed three times with the vacuum using 5 mL amounts of DI water. After the crystals were completely dry, the beaker was weighed a second time, including the crystals, in order to obtain the actual yield of synthesized aspirin: This value was used, along with the theoretical yield value, to calculate the percent yield of the synthesized aspirin: Caution — acetic anhydride, salicylic acid, and phosphoric acid are all toxic chemicals and should not come into contact with the skin.
CDCl3, used later for spectroscopy, is also a toxic chemical. Next, NaOH was used to titrate commercial aspirin tablets — one tablet of aspirin, weighing mg, was dissolved in methanol, and then 10 mL of DI water and 4 drops of phenolphthalein indicator were added.
This mixture was generated a total of three times, so as to have three separate flasks with identical mixtures for three trials. The starting reading of NaOH was recorded. Titration was then performed in three trials, each by adding NaOH to the mixture in the flask until the mixture turned light pink and maintained this color for 15 seconds.
The end point reading of NaOH was recorded. To finish the experiment, three titration trials were performed using the synthesized aspirin. DI water and four drops of phenolphthalein were added, and the same process of titration was used.
All three synthesized aspirin titrations yielded a light pink color for 15 seconds, thus each trial was successful and used in calculations. The synthesized aspirin was also used in two different types of spectroscopy:Organic Synthesis Aspirin Aim Biology Essay To synthesise acetylsalicylic acid, to find the pureness of acetylsalicylic acid utilizing chemical trial, and to find the per centum of output acetylsalicylic acid.
Aspirin Synthesis and Analysis. Synthesis of Aspirin Lab Report. SUMMARY AND CONCLUSION Organic synthesis is a process of converting a starting material to a certain product through various reactions and observations.
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The preparation of aspirin. PREPARATION OF ACETYLSALICYLIC ACID (ASPIRIN) The Aspirin Synthesis Reaction Aspirin is known to be unstable in the presence of moisture at elevated. Designing an experiment that incorporates the synthesis of salicylic acid from a natural source, such as the flowers of the meadowsweet plant, wintergreen plant, or bark from the willow tree, and utilizing the salicylic acid to make a more natural product used to.
Introduction. Acetylsalicylic acid is the chemical name for aspirin, the ubiquitous pain reliever. One of the compounds used in the synthesis of aspirin is salicylic acid, which is itself a pain reliever that was known to many ancient cultures, including the Native Americans who extracted it from willow tree bark.
Abstract: The synthesis of aspirin is a part of many undergraduate organic synthesis labs and is frequently used in qualitative organic analysis laboratory for the identification of salicylic acid. We have found that aspirin can be synthesized on microscale by a.